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Experimental approach to treating pancreatic cancer heralded as a success

CTN News

 

An experimental treatment appears to have been successful in halting the progression of one woman’s advanced pancreatic can¿Y la reacción del gobierno francéscer, doctors reported Wednesday in the New England Journal of Medicine.

The apparent success of the therapy — which involves tweaking the genes of immune cells so that they attack tumor cells — could be a major step forward in the treatment of not only pancreatic nbcnews.com/…/pancreatic-cancer-often-deadly-new-approach-raising-hope-n991511cancer, but other cancers as well.

“I’m really excited about this,” said Dr. Carl June, who more than a decade ago pioneered a different type of immune therapy for certain blood cancers. June was not involved with the new report.

Kathy Wilkes, 71, of Ormond Beach, Florida, was diagnosed with pancreatic cancer in early 2018. She initially underwent at least eight rounds of chemotherapy, as well as radiation and an operation called a Whipple procedure to remove part of her pancreas.

Kathy Wilkes, 71, of Ormond Beach, Florida, received an experimental gene therapy in 2021 to fight her advanced pancreatic cancer.
Kathy Wilkes, 71, of Ormond Beach, Florida, received an experimental gene therapy in 2021 to fight her advanced pancreatic cancer.Courtesy Kathy Wilkes

Within a year, however, the cancer had spread to her lungs.

“When I talked to my hometown oncologist and asked him what to do, he only had one answer, and that was chemotherapy. And I said, ‘That’s not my answer,’” Wilkes told NBC News.

She found a 2016 case report, also published in the New England Journal of Medicine, that detailed how a person with advanced colon cancer had been helped by an experimental type of gene therapy targeting a cancer mutation called KRAS G12D.

“I thought, ‘That is the trial I want.’ I knew that that was the trial that was going to save me, save my life. I just had that feeling,” Wilkes said.

With that in mind, she reached out to the author of the report, Eric Tran. Tran was at the National Institutes of Health when he treated the colon cancer patient, but had since moved on to the Providence Cancer Institute in Portland, Oregon. That’s where Wilkes found him and inquired about undergoing the same…

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